Admin Why is G-CSF given?
G-CSF (granulocyte-colony stimulating factor) is a type of protein called a growth factor. It increases the number of some types of white blood cells in the blood. It can be used with chemotherapy. It can also be used before and after a stem cell transplant.
When do you give G-CSF?
Patients should receive GCSF from day five until bone marrow recovery. Doses should be rounded to the nearest vial or pre-filled syringe size. G-CSF should not be administered within 24 hours of cytotoxic chemotherapy. The recommended start date is 3 days after the administration of chemotherapy.
What are colony stimulating factors used for?
The colony-stimulating factors (CSFs) represent the only biological response modifiers used in clinical practice to treat or prevent neutropenia. These pleiotropic cytokines are available in clinical practice as granulocyte CSF (G-CSF), granulocyte-macrophage CSF (GM-CSF) and pegylated G-CSF.
What is G-CSF in immunology?
Abstract. Granulocyte colony-stimulating factor (G-CSF) is a pleiotropic cytokine playing a major role as regulator of hematopoiesis and innate immune responses.
What is G-CSF pegfilgrastim used for?
It is used to reduce the incidence of fever and infection in patients with certain types of cancer who are receiving chemotherapy that affects the bone marrow, to stimulate blood cell production for removal of WBCs from the body prior to a bone marrow transplantation, to reduce the incidence of fever and infection in …
What is Filgrastim used for?
Filgrastim injection is used to treat neutropenia (low white blood cells) that is caused by cancer medicines. It is a synthetic (man-made) form of a substance that is naturally produced in your body called a colony stimulating factor. Filgrastim helps the bone marrow to make new white blood cells.
What cells release colony-stimulating factor?
Colony-stimulating factors are hematopoietic growth factors that induce clonal growth of hematopoietic progenitors in vitro and in vivo. They are produced by macrophages, stromal cells, endothelial cells, and T lymphocytes in the marrow microenvironment.
Where is G-CSF secreted?
G-CSF is produced by endothelium, macrophages, and a number of other immune cells.
Which cells produce G-CSF?
Human G-CSF is produced mainly by monocytes and macrophages (2), but is also produced by fibroblasts (3), endothelial cells (4), and bone marrow stromal cells (5).