What type of reaction creates aspirin?

What type of reaction creates aspirin?

Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride.

What is the chemical equation for aspirin?

Aspirin C9H8O4 is made when salicylic acid C7H6O3 reacts with ethanoic anhydride C4H6O3 . The equation for this reaction is: C7H6O3 + C4H6O3 → C9H8O4 + CH3COOH Calculate the maximum mass of aspirin that could be made from 100 g of salicylic acid.

Is the synthesis of aspirin a condensation reaction?

When an alcohol is allowed to react with a carboxylic acid in the presence of an acid catalyst, the functional groups combine in a condensation reaction to form an ester and water: Page 3 By reacting the phenol group of salicylic acid with acetic acid, an ester group (which is not acidic) is formed and the resulting …

Is aspirin a chemical change?

in the crushing of aspirin there is no chemical change. The molecules are the same in the small structures of the powered aspirin as in the entire pill. Since there is no chemical reaction or change in the composition of crushed aspirin in relationship to non crushed aspirin, Crushing aspirin is a physical change.

What is esterification reaction?

Esterification is a chemical reaction that forms at least one ester (= a type of compound produced by reaction between acids and alcohols). Esters are produced when acids are heated with alcohols in a process called esterification. An ester can be made by an esterification reaction of a carboxylic acid and an alcohol.

How aspirin is metabolized?

Therefore, aspirin has a very short half-life. Salicylate, in turn, is mainly metabolized by the liver. This metabolism occurs primarily by hepatic conjugation with glycin or glucuronic acid, each involving different metabolic pathways. The predominant pathway is the conjugation with glycin, which is saturable.

How do you synthesis aspirin?

SYNTHESIS OF ASPIRIN (acetylsalicylic acid)

1. Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask.
2. Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc.
3. Heat the flask gently on the steam bath for at least 10 minutes.
4. Allow the flask to cool to room temperature.

What type of reaction is Fischer esterification?

Overview. Fischer esterification is an example of nucleophilic acyl substitution based on the electrophilicity of the carbonyl carbon and the nucleophilicity of an alcohol. However, carboxylic acids tend to be less reactive than esters as electrophiles.

What is meant by a condensation reaction?

condensation reaction, any of a class of reactions in which two molecules combine, usually in the presence of a catalyst, with elimination of water or some other simple molecule.

What type of reaction is esterification?

Esterification is a reversible reaction. Esters undergo hydrolysis under acid and basic conditions. Under acidic conditions, the reaction is the reverse reaction of the Fischer esterification. Under basic conditions, hydroxide acts as a nucleophile, while an alkoxide is the leaving group.

What is the chemical equation for the synthesis of aspirin?

What Is the Chemical Equation for the Synthesis of Aspirin? The chemical equation for the synthesis of aspirin is C7H6O3 + C4H6O3 –> C9H8O4 +C2H4O2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. The byproduct is acetic acid.

How is aspirin made from salicylic acid?

Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. It is odourless, colourless to white crystals or crystalline powder.

What happens when you take aspirin and alcohol together?

Taking aspirin and alcohol together can increase the risk of gastric bleeding 1,3. Inside the body, aspirin is converted into its active metabolite salicylate. This happens mostly in the liver. Peak concentration of salicylate in the plasma occurs approximately 1-2 hours after ingestion. Excretion from the body is mainly through the kidney.

How is aspirin excreted from the body?

Inside the body, aspirin is converted into its active metabolite salicylate. This happens mostly in the liver. Peak concentration of salicylate in the plasma occurs approximately 1-2 hours after ingestion. Excretion from the body is mainly through the kidney. Alkaline urine speeds up the excretion of aspirin.