What is the molecular formula of clopidogrel?

What is the molecular formula of clopidogrel?

C16H16ClNO2S·C6H5SO3H
Clopidogrel/Formula

What is the chemical structure of Plavix?

Chemically it is methyl (+)-(S)-α (2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate sulfate (1:1). The empirical formula of clopidogrel bisulfate is C16H16ClNO2S•H2SO4 and its molecular weight is 419.9.

What is clopidogrel bisulfate?

Plavix (clopidogrel bisulfate) is a thienopyridine class of drug that inhibits platelet aggregation and thus inhibits aspects of blood clotting used to treat patients with acute coronary syndrome, myocardial infarction (MI), peripheral vascular disease and some stroke (ischemic type) patients.

Is there a difference between clopidogrel and clopidogrel bisulfate?

Plavix for oral administration is provided as either pink, round, biconvex, debossed, film-coated tablets containing 97.875 mg of clopidogrel bisulfate which is the molar equivalent of 75 mg of clopidogrel base or pink, oblong, debossed film-coated tablets containing 391.5 mg of clopidogrel bisulfate which is the molar …

Is Clopidogrel bisulfate an anticoagulant?

Plavix (clopidogrel bisulfate) and Coumadin (warfarin) are anticoagulants (blood thinners) used to treat patients with acute coronary syndrome, heart attack (myocardial infarction), peripheral vascular disease, and ischemic strokes.

How is Clopidogrel metabolized?

Metabolism of clopidogrel Clopidogrel is a prodrug that requires metabolic activation in two steps (Figure 1). The majority of the clopidogrel dose (>85%) is metabolized to inactive clopidogrel-carboxylic acid by human carboxylesterase 1 (CES1) [Tang et al. 2006].

How is Plavix metabolized?

Plavix works by decreasing the activity of blood cells called platelets, making platelets less likely to form blood clots. For Plavix to work, enzymes in the liver (particularly CYP2C19) must convert (metabolize) the drug to its active form.

Is clopidogrel bisulfate an anticoagulant?

How is clopidogrel metabolized?

Is Clopidogrel bisulfate a blood thinner?

Generic versions of blood-thinning medication – Plavix (clopidogrel bisulfate) – have been approved by the FDA (Food and Drug Administration). Clopidogrel bisulfate reduces the likelihood of blood platelets clumping together and forming clots in blood vessels, resulting in a lower risk of stroke and heart attack.

Is clopidogrel like Heparin?

Clopidogrel is a P2Y12 inhibitor, the same class of drugs that also includes prasugrel (Effient) and ticagrelor (Brilinta). Clopidogrel is similar to ticlopidine (Ticlid) in chemical structure and in the way it works. Heparin is a widely used injectable anticoagulant used to stop blood clots.

What is the mechanism of action of clopidogrel bisulfate?

Clopidogrel Bisulfate is a thienopyridine with antiplatelet activity. Clopidogrel bisulfate irreversibly alters the platelet receptor for adenosine diphosphate ( ADP ), thereby blocking the binding of ADP to its receptor, inhibiting ADP -mediated activation of the glycoprotein complex GPIIb/IIIa,…

Is clopidogrel bisulfate soluble in methanol?

Clopidogrel bisulfate is a white to off-white powder. It is practically insoluble in water at neutral pH but freely soluble at pH 1. It also dissolves freely in methanol, dissolves sparingly in methylene chloride, and is practically insoluble in ethyl ether.

What is the molecular weight of clopidogrel?

Molecular Weight: 419.9. Parent Compound: CID 60606 (Clopidogrel) Component Compounds: CID 1118 (Sulfuric acid) CID 60606 (Clopidogrel) Dates

How does clopidogrel (clonidine) work?

Clopidogrel targets, irreversibly binds to and alters the platelet receptor for adenosine diphosphate ( ADP ), thereby blocking the binding of ADP to its receptor, inhibiting ADP -mediated activation of the glycoprotein complex GPIIb/IIIa, and inhibiting fibrinogen binding to platelets and platelet adhesion and aggregation.