What is contraindicated with Depakote?

What is contraindicated with Depakote?

Depakote is contraindicated in patients known to have mitochondrial disorders caused by mutations in mitochondrial DNA polymerase γ (POLG; e.g., Alpers-Huttenlocher Syndrome) and children under two years of age who are suspected of having a POLG-related disorder [see Warnings and Precautions (5.1)].

Can you take melatonin with Depakote?

MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation.

Can I take Benadryl with divalproex?

Using diphenhydrAMINE together with divalproex sodium may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.

Is Depakote DR and er the same?

Available in two strengths, Depakote ER contains the same active ingredient as Depakote Delayed-Release Tablets but it is designed to slowly deliver the medication over a 24-hour period. This means that Depakote ER only has to be taken once a day.

Can you take sleeping pills with Depakote?

Interactions between your drugs Using zolpidem together with divalproex sodium may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.

Can you take Tylenol PM with Depakote?

No interactions were found between Depakote and Tylenol.

Does Depakote interact with other medications?

Other antidepressants known to interact with Depakote are Zoloft, Abilify, and Cymbalta. Interactions of Depakote with these are similar to that with Lexapro. Using Depakote in combination with amitriptyline tends to elevate the amitriptyline level in the blood.

Can Depakote and zidovudine be taken together?

Combining Depakote with zidovudine (ZDV), also known as azidothymidine (AZT), tends to increase the ZDV level in the blood and also increases the risk of side effects associated with it. The doctor may increase the dosage of zidovudine as per required. Drug interaction with felbamate

What happens if you take Depakote and topiramate together?

Depakote taken along with topiramate causes hyperammonemia by increasing the level of ammonia in the blood. In mild cases of hyperammonemia, symptoms may be absent, but in severe cases, it may cause lethargy, mental changes, and vomiting. The doctor may monitor your condition and adjust the dosage as needed.

Can Depakote and carbapenems be taken together?

Carbapenems, a class of antibiotics, tends to decrease the level of Depakote in the blood. Thus, Depakote’s effect is reduced. The health care provider will first monitor the condition of the patient and adjust the dose of Depakote as needed. Aspirin taken along with Depakote can cause negative interactions.