What does cell autonomy mean?

What does cell autonomy mean?

A genetic trait in multicellular organisms in which only genotypically mutant Cells exhibit the mutant phenotype. Conversely, a nonautonomous trait is one in which genotypically mutant Cells cause other Cells (regardless of their genotype) to exhibit a mutant phenotype.

What is non cell autonomous mean?

Cell Autonomous: A genevc trait in mulvcellular organisms in which only genotypically mutant cells exhibit the mutant phenotype. Conversely, a nonautonomous trait is one in which genotypically mutant cells cause other cells (regardless of their genotype) to exhibit a mutant phenotype.

What is non cell autonomous effects?

Any phenotypic difference seen between the neurons of the same genotype, but present in distinct genotypic environments indicate non-cell-autonomous effects.

What is autonomy of tumor cell growth?

Autonomous replication of tumor cells seems to be an essential factor in the definition of the malignant tumor itself, although tumor cell proliferation is, in general, controlled by the host response including immunological reactions and microenvironment.

What are autonomous cell organelles?

The organelles which can survive on their own, have their own independent genetic material, can independently replicate, during cell division, they pass their own genetic material along with the cellular DNA are termed as semi-autonomous organelles. Hence, they are called semi autonomous organelles.

What are cell autonomous effects?

Cell-autonomous effects (henceforth referred to as “CA effects”) are the properties conferred to a cell by the accumulation of genetic and epigenetic alterations.

What causes tumorigenesis?

Macrophages and neutrophils in an inflamed colonic epithelium are the source of reactive oxygen species causing the DNA damage that initiates colonic tumorigenesis, and bile acids, at high levels in the colons of humans eating a high-fat diet, also cause DNA damage and contribute to colon cancer.

What is cell autonomy/nonautonomy analysis?

– The cell(s) in which removal of wild-type gene activity results in a mutant phenotype and/or – The cell(s) in which the presence of wild-type gene activity is necessary for a wild-type phenotype. Cell autonomy/nonautonomy analysis is necessary in metazoans to provide an organismal context for gene and pathway function.

What is an autonomous cell?

Here is a pretty good cell autonomous definition from the Holmgren group at Northwestern. It states: A genetic trait in multicellular organisms in which only genotypically mutant cells exhibit the mutant phenotype.

What is cell nonautomy?

a) Cell nonautomy: when phenotype and genotype of cells are not concordant – a genotypically mutant cell may cause a genotypically wild-type cell to exhibit a mutant phenotype. and/or – a genotypically wild-type cell may rescue a genotypically mutant cell.

What is a nonautonomous trait in biology?

A genetic trait in multicellular organisms in which only genotypically mutant cells exhibit the mutant phenotype. Conversely, a nonautonomous trait is one in which genotypically mutant cells cause other cells (regardless of their genotype) to exhibit a mutant phenotype.