What are the side effects of phenothiazines?

What are the side effects of phenothiazines?

Constipation, trouble urinating, dryness of mouth, confusion, problems with memory, dizziness or fainting, drowsiness, trembling of the hands and fingers, and problems with muscle movement, such as decreased or unusual movements, are especially likely to occur in elderly patients, who are usually more sensitive than …

What are phenothiazines used for?

Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients.

What are some examples of phenothiazines?

Examples of phenothiazines include: chlorpromazine (brand name: Thorazine), fluphenazine (Duraclon), mesoridazine (Serentil), perphenazine (Etrafon and Trilafon), prochlorperazine (Compazine), promazine (Robinul and Anectine), thioridazine (Mellaril), trifluoperazine (Stelazine) and triflupromazine (Robinul).

What is a serious and irreversible side effect of phenothiazines?

Phenothiazines can sometimes cause serious unwanted effects. Tardive dyskinesia or tardive dystonia (muscle movement disorders) may occur and may not go away after you stop using the medicine.

Does phenothiazines cause weight gain?

Adverse Effects Extrapyramidal symptoms, including dystonia, parkinsonism, akathisia, and tardive dyskinesia. Weight gain.

What is the use of amitriptyline?

Amitriptyline is a medicine used for treating pain. You can take it: to treat nerve pain (neuralgia) and back pain. to help prevent migraine attacks.

What is the mechanism of action of phenothiazines?

Although, the exact mechanism of phenothiazine antipsychotics is unknown, scientists believe that they may work by blocking the action of dopamine in the brain. Dopamine is a neurotransmitter (chemical) that nerves use to communicate with one another.

How do Thioxanthenes work?

They work as dopamine-2 (D2) receptor antagonists and suppress the effect of dopamine in the brain. Thioxanthenes are high potency drugs: they have a high affinity for dopamine receptors compared to affinity for adrenergic and muscarinic receptors. Thioxanthene antipsychotics are used to treat schizophrenia.

Do phenothiazines cause physical dependence?

Although phenothiazines cause neither psychic nor physical dependence, sudden discontinuance in long-term psychiatric patients may cause temporary symptoms, e.g., nausea and vomiting, dizziness, tremulousness. Note: There have been occasional reports of sudden death in patients receiving phenothiazines.

Can perphenazine cause liver damage?

Introduction. Perphenazine is a phenothiazine and antipsychotic agent, now rarely used in clinical practice. Perphenazine can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute and chronic cholestatic liver injury.

What are the bad side effects of amitriptyline?

Amitriptyline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea.
• vomiting.
• drowsiness.
• weakness or tiredness.
• nightmares.
• headaches.
• dry mouth.
• constipation.

Can taking amitriptyline long term cause problems?

Amitriptyline is safe to take for a long time. There do not seem to be any lasting harmful effects from taking it for many months or years.

What are phenothiazines used to treat?

Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients.

What are the possible side effects of phenothiazine antipsychotics?

Some phenothiazine antipsychotics are prescribed to treat nausea, vomiting, and hiccups. Common side effects include drowiness, headache, low blood pressure, blurred vision, and dizziness. Warnings, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to taking phenothiazine antipsychotics.

What is the difference between chlorpromazine and phenothiazine?

Phenothiazines are neuroleptic agents that affect a variety of receptors including dopaminergic receptor sites. Chlorpromazine was the first of the phenothiazines used clinically as an antipsychotic. Phenothiazines are used to treat psychosis including schizophrenia; violent, agitated, disturbed behavior; and mania secondary to bipolar disorder.

What medications should not be taken with phenothiazine?

Phenothiazine antipsychotics should not be combined with other antipsychotics or medications that cause extra-pyramidal side effects and neuroleptic malignant syndrome due to an increased likelihood of these side effects.