How is Fragile X syndrome passed?

How is Fragile X syndrome passed?

The gene for Fragile X is carried on the X chromosome. Because both males (XY) and females (XX) have at least one X chromosome, both can pass on the mutated gene to their children. A father with the altered gene for Fragile X on his X chromosome will pass that gene on only to his daughters.

Is Fragile X autosomal or Sexlinked?

Fragile X syndrome is a sex-linked dominant trinucleotide repeat disorder (other trinucleotide repeat disorders include Huntington chorea, spinocerebellar ataxia, myotonic dystrophy and Friedreich ataxia).

Is Fragile X syndrome recessive?

Fragile X syndrome is considered to be an X-linked dominant condition with variable expressivity and reduced penetrance. [5] However, due to X-inactivation in females and genetic anticipation, the inheritance of FXS does not follow standard X-linked dominant inheritance.

How can a genetic condition be inherited?

Genetic disorders are precisely what they sound like: Diseases caused by a mutation of a gene. When such diseases are inherited (rather than the result of a random mutation), it means they are passed along to a child from one or both parents according to a specific patterns of inheritance.

What is a fractured chromosome?

Description: Chromosome breakage disorders are a group of related diseases which are characterized by spontaneous chromosome breakage, immunodeficiency and predisposition to malignancy. These conditions include Fanconi Anemia, Ataxia-Telangiectasia, Bloom syndrome, LIG4 syndrome, and Nijmegen breakage syndrome.

How do you determine inheritance patterns?

By analyzing a pedigree, we can determine genotypes, identify phenotypes, and predict how a trait will be passed on in the future. The information from a pedigree makes it possible to determine how certain alleles are inherited: whether they are dominant, recessive, autosomal, or sex-linked.