Does aliskiren increase blood pressure?

Does aliskiren increase blood pressure?

We found that aliskiren, which lowered blood pressure (BP) effectively in patients with mild-to-moderate hypertension, was similar to HCTZ but inferior to CCBs in BP reduction, response rates and control rates.

What is the classification of aliskiren?

Aliskiren is in a class of medications called direct renin inhibitors. It works by decreasing certain natural chemicals that tighten the blood vessels, so blood vessels relax and the heart can pump blood more efficiently.

Is renin a vasoconstrictor or vasodilator?

In this construct prorenin (renin I) is the vasodilator limb and renin (renin IT) is the vasoconstrictor limb of a long-term cardiovascular control system that regulates blood pressure and tissue perfusion.

Does aliskiren increase potassium?

Medications that raise potassium levels – aliskiren has the potential to raise potassium levels and cause hyperkalemia. When combined with other potassium-raising medications, the risk is increased.

How does aliskiren reduce blood pressure?

Aliskiren is a renin inhibitor. It works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax and this decreases the blood pressure.

Is aliskiren and ACE inhibitor?

Aliskiren is an orally-active, nonpeptidic, direct inhibitor of renin which simultaneously reduces angiotensin I, angiotensin II and plasma renin activity (PRA). This is the main point of action of aliskiren, making it completely different from ACE inhibitors and ARBs.

Is aliskiren renin inhibitor?

Aliskiren is an orally effective direct renin inhibitor that blocks the generation of angiotensin I from angiotensinogen, the rate limiting step of RAAS activation. Studies have shown equivalent antihypertensive efficacy of aliskiren when compared to existing medications such as HCTZ, ACE inhibitors and ARBs.

Is aldosterone a vasoconstrictor?

Aldosterone causes vasoconstriction in coronary arterioles, and this vasoconstrictor effect is enhanced by genetically defined hypertension. Aldosterone-induced vasoconstriction is mediated by angiotensin AT1 receptor presumably via oxidative stress.

Is angiotensin II a vasodilator or vasoconstrictor?

Conclusion— Angiotensin is converted locally into Ang II; the overall effect of Ang II is vasoconstrictor following stimulation of the AT1 receptor, but a vasodilator response can be evoked following stimulation of the AT2 receptor and activation of BKCa.

Is aliskiren a diuretic?

Aliskiren works by relaxing blood vessels so blood can flow more easily. It belongs to a class of drugs known as direct renin inhibitors. Hydrochlorothiazide causes your body to get rid of extra salt and water by making more urine. It is called a “water pill” or diuretic.

What is the mechanism of action of aliskiren?

Aliskiren is the first and only approved direct renin inhibitor. The mechanism of action of this drug is unique in that it blocks the RAAS by binding to a pocket in renin itself, preventing it from cleaving angiotensinogen to angiotensin I.

Is aldosterone a vasodilator?

In vascular endothelial cells, aldosterone activation of GPER mediates vasodilation. In contrast, activation of endothelial mineralocorticoid receptors has been linked to enhanced vasoconstrictor and/or impaired vasodilator responses.

How does aliskiren work?

Aliskiren is a renin inhibitor. It works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax and this decreases the blood pressure.

How effective is aliskiren as an antihypertensive drug?

Normal therapeutic concentrations of aliskiren reduce plasma renin activity by 50-80%. It is effective as monotherapy. When used in conjunction with thiazide diuretics or ARBs, the antihypertensive effects are additive. Aliskiren alone, like ACEIs and ARBs, has a relatively low incidence of side effects and is well-tolerated.

How is aliskiren metabolized and excreted?

It is metabolized by the liver and excreted by the kidneys. Normal therapeutic concentrations of aliskiren reduce plasma renin activity by 50-80%. It is effective as monotherapy. When used in conjunction with thiazide diuretics or ARBs, the antihypertensive effects are additive.

Does aliskiren interact with other medications or foods?

NSAIDs ( nonsteroidal anti-inflammatory drugs )– aspirin, ibuprofen ( Advil, Motrin ), naproxen ( Aleve ), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may interact with aliskiren, including prescription and over-the-counter medicines, vitamins, and herbal products.