Admin Table of Contents
Is apomorphine water soluble?
This product is soluble in water (~10 mg/mL), yielding a clear, yellow to green solution. A 1% solution in water has a pH of 4.0-5.0.
What type of receptors does apomorphine act on?
Apomorphine is a non-ergoline dopamine agonist with high binding affinity to dopamine D2, D3, and D5 receptors. Stimulation of D2 receptors in the caudate-putamen, a region of the brain responsible for locomotor control, may be responsible for apomorphine’s action.
What is the mechanism of action of apomorphine?
Apomorphine causes vomiting by acting on dopamine receptors in the chemoreceptor trigger zone of the medulla; this activates the nearby vomiting center.
Is metoclopramide an acid or base?
It is a tertiary amino compound, a substituted aniline, a member of benzamides and a member of monochlorobenzenes. It is a conjugate base of a metoclopramide(1+).
Does apomorphine cause vomiting?
Severe nausea and vomiting are commonly induced by apomorphine and can be controlled by pretreatment for a few days with oral or rectal domperidone 20 to 30 mg three times daily.
Can apomorphine be reversed?
Previous data have shown that apomorphine-induced respiratory depression can be reversed by the opiate antagonist, naloxone.
Is apomorphine an agonist?
Apomorphine injection is in a class of medications called dopamine agonists. It works by acting in place of dopamine, a natural substance produced in the brain that is needed to control movement.
Is bromocriptine a dopamine agonist?
Bromocriptine is a sympatholytic D2-dopamine agonist that has been approved for the treatment of type 2 diabetes.
Is apomorphine a dopamine agonist?
Is metoclopramide a prokinetic?
Metoclopramide is extensively used as an intravenous prokinetic drug to treat delayed gastric emptying and to facilitate early enteral feeding.
Does apomorphine cross the blood brain barrier?
The hydrophilic character of apomorphine allows it to be solubilized and therefore, formulated as an aqueous solution. Moreover, it is readily mixed in tissue fluids and can be absorbed into the systemic circulation and subsequently cross the lipophilic blood-brain barrier [14].