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What type of mutation changes the reading frame?
A frameshift mutation is a genetic mutation caused by a deletion or insertion in a DNA sequence that shifts the way the sequence is read.
Does mutation affect reading frame?
Frameshift Mutation Each group of three bases corresponds to one of 20 different amino acids used to build a protein. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly.
Which type of mutation does not result in a frame shift?
Insertion or deletion of three (or multiples of 3) nucleotides does not result in a frameshift mutation. It only results in the presence (or absence) of some amino acids in the polypeptide. 2. How can a frameshift mutation caused by a single nucleotide drastically change the length of a polypeptide?
Which mutation affects the reading frame during translation?
A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three.
What type of mutation alters the reading frame in the mRNA downstream of the mutation?
Explanation: A frameshift mutation indicates that the reading frame of the sequence in altered, resulting in production of different codons downstream of the mutation.
What is an out of frame mutation?
A deletion is out-of-frame if the reading frame is completely disrupted, so that no dystrophin protein can be made. Out-of-frame deletions typically result in Duchenne muscular dystrophy, which usually has a more severe presentation (compared to Becker) because there is no dystrophin protein present in the cells.
What is an example of silent mutation?
Silent mutations are base substitutions that result in no change of the amino acid or amino acid functionality when the altered messenger RNA (mRNA) is translated. For example, if the codon AAA is altered to become AAG, the same amino acid – lysine – will be incorporated into the peptide chain.
What type of mutation does not alter the amino acid sequence?
A silent mutation is a mutation that occurs within the DNA sequence, but does not alter the amino acid sequence. Silent mutations can occur in introns, which are spliced out before translation.
Which type of mutation stops the translation of the MRNA?
Nonsense mutation: changes an amino acid to a STOP codon, resulting in premature termination of translation.