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How does granulation affect dissolution?
A statistical analysis revealed that the amount of granulation liquid (w/w%) and the ratio of water to ethanol in the liquid (v/v%) significantly affected the dissolution property, and that the drying temperature had a significant effect on the physical stability.
What are the advantages of granulation?
1 Introduction
| Wet granulation | |
|---|---|
| Advantages | • More uniform mixing than dry granulation • More binding in less quantity of binder • Better content uniformity • Suitable for very low to very high drug content • Reduces sticking of blend to compression tooling |
What are the advantages of granules over powders?
Granules have smaller surface area than a comparable volume of pow-ders. This makes granules more stable physically and chemically than the corresponding powders. Granules are less likely to cake or harden upon standing than are powders. Granules produce particle – size uniformity, thus content uniformity6.
Why granulation is important in tablet preparation?
The purpose of dry granulation is to increase the bulk density of powders and increase the particle size to ensure a better flow of distributed material — an important factor in the production of tablets and capsules using high speed manufacturing equipment.
Why granulation process is important prior to tablet compression?
Granulation process is an inevitable step in tablet manufacturing as it improves flow property and compressibility of powder mass intended for compression. Granulation prevents segregation of the constituents of the powder mix.
What are granules used for?
Granules contain one or more active substances with or without excipients and, if necessary, suitable colouring and flavouring substances. They are mainly used for low-toxicity, high-dose drugs.
Are granules bigger than powder?
A granular material is a conglomeration of discrete solid, macroscopic particles characterized by a loss of energy whenever the particles interact (the most common example would be friction when grains collide). A powder has a smaller grain size and granular probably consists of bigger grains.
What is the difference between granules and tablets?
One of the primary differences between granules and capsules is the ease and convenience of the capsule format — a dosage form that most consumers are highly accustomed to today. For easy dosing, capsules are filled with 500 mg of granule herbs.
How does granulation improve flowability?
It was shown that the flowability increases as the size of the granules increases for all materials considered. Furthermore, it was found that there is a strong correlation between the critical filling speed and the flow index: the critical filling speed is proportional to the flow index to a power of − 5/2.
Why is a tablet binder necessary for granulation?
Tablet binders are one of the most essential elements in the formulation of a tablet. Because they promote cohesiveness, the binders, also called adhesives, help the other ingredients in a tablet to mix together. Tablet binders are used to turn powder to granules; this is achieved through the process of granulation.
Do granulation process variables affect physical properties of granules and tablets?
Effects of granulation process variables on the physical properties of dosage forms by combination of experimental design and principal component analysis The current study was to understand how process variables of high shear wet granulations affect physical properties of granules and tablets.
Do hard granules reduce disintegration and dissolution time of tablets?
Hard granules might reduce the disintegration and dissolution time of tablet. Liquid to solid ratio (L/S) i.e. quantity of granulating liquid used in granulation is an important variable that could affect the granule properties in high shear granulation.
Does moisture present in granules affect the tablet ejection force?
Moreover, moisture present in granules could affect the tablet ejection force because of its lubricating properties. The effects of MC on tablet porosity have been reported previously [12], [16], [17], [18].
Do ascorbic acid granules affect tablet properties?
By using five different sieve sizes of ascorbic acid granules, affects of granule sizes on tablet properties, i.e. tablet weight and hardness have been studied with standard methods.